Neurofibromatosis
Type I
•Café au lait macules (CALMs) are uniformly pigmented flat spots that range in size from a few mm to as much as 30cm in adults. CALMs increase in size in proportion to growth.
•One or two CALMs are common more than 6 raises the concern about NF-1
•Of children who present with 6 or more CALMs 89% meet the diagnostic criteria for NF-1 within 3 years.