NAME: Lawrence M. Grover

ADDRESS:
Department of Physiology
Marshall University School of Medicine
1542 Spring Valley Drive
Huntington, WV 25755-9340

Telephone: 304-696-7328
Fax: 304-696-7381
Email:
grover@marshall.edu

EDUCATION:
1982, B.S. Psychology, The University of the South, Sewanee, TN
1984, M.A. Psychology and Neuroscience, Princeton University, Princeton, NJ
1986, Ph.D. Psychology and Neuroscience, Princeton University, Princeton, NJ

HONORS AND AWARDS:
1978-82, National Merit Scholar, The University of the South, Sewanee, TN
1985-86, Harold W. Dodds Fellow, Princeton University, Princeton, NJ

PROFESSIONAL EXPERIENCE:

1982-1985, Assistant Instructor, Department of Psychology, Princeton University, Princeton, NJ
1983-1985, Research Assistant, Department of Psychology, Princeton University, Princeton, NJ
1986-1987, Research Associate, Department of Psychology, Princeton University, Princeton, NJ
1988-1992, Research Associate, Neurobiology Department, N.E. Ohio Universities College of Medicine, Rootstown, OH (Leave of absence, 1990-1991)
1990-1991, Lecturer, Department of Psychology, University of Washington, Seattle, WA
1992-1993, Research Assistant Professor, Neurobiology Department, N.E. Ohio Universities College of Medicine, Rootstown, OH
1993-present, Assistant Professor, Department of Physiology, Marshall University School of Medicine, Huntington, WV

PROFESSIONAL AFFILIATIONS:
1985-present, Society for Neuroscience
1996-present, American Physiological Society

TEACHING EXPERIENCE:
1. University of Washington (undergraduate):
Physiological Psychology
Advanced Physiological Psychology
Seminar in Learning and Memory

2. N.E. Ohio Universities College of Medicine (graduate):

Neurophysiology

3. Marshall University School of Medicine (undergraduate, graduate and medical):

Cellular and Molecular Biology (BMS600)
Physiology of the Cell (PHS 666)
Neuroscience (BMS 630, IDM 777)
Mammalian Neurophysiology (PHS 628)
Neurophysiology Literature Review (PHS 637)
Recent Advance in Physiology (PHS 641)
Neurophysiology Research Techniques (PHS639)
Molecular Biology (BSC 450/550)
Molecular Signal Transduction (BIC 643)

INDSTITUTIONAL AND PROFESSIONAL SERVICE:

Faculty advisor, Program to Encourage Minority Scientists, Marshall University School of Medicine, 1994-1997.

Recruitment trip for Marshall University School of Medicine to West Liberty State, Bethany and Wheeling Jesuit Colleges, March 30-31, 1995. Seminar "How Does the Brain Store Memories?", Bethany College, March 30, 1995.

Judge, Research Day, Marshall University School of Medicine, 1995, 1997.

Successful application for Spring 1996 Grass Foundation Traveling Scientist in Neuroscience (Dr. Neil Harrison, Department of Anesthesiology and Critical Care, University of Chicago), Marshall University School of Medicine.

Outside evaluation for promotion review of Dr. Andrzej Wieraszko, Biology Department, College of Staten Island, City University of New York, 1996.

Department of Physiology Tenure and Promotion Committee, 1996.

Marshall University School of Medicine Personnel Committee, 1996-1998.

Marshall University School of Medicine Ad Hoc Committee on Graduate Student Recruitment, 1997.

Marshall University School of Medicine External Institutional Relationship Committee, 1997.

Reviewer for 1998 Conference of Southern Graduate Schools Master's Thesis Award.

Reviewer for Brain Research, Brain Research Bulletin, Experimental Neurology, Journal of Neurochemistry, Journal of Neurophysiology, Journal of Neuroscience, Neuroscience.

RESEARCH INTERESTS:

Neural basis of learning and memory. Synaptic plasticity. Excitatory and inhibitory amino acid neurotransmission. Neurotransmitter and second messenger regulation of neuronal excitability and synaptic transmission. Synaptic physiology of the hippocampus.

DOCTORAL DISSERTATION:

Conditioning-produced short-term neural and behavioral changes in Hermissenda: Ionic basis of, and neurotransmitter involvement in cumulative depolarization of the Type B photoreceptor. Princeton University, 1986.

INVITED SEMINARS:

1987, Neurobiology Department, N.E. Ohio Universities College of Medicine, Rootstown, OH
1990, Department of Physiology and Biophysics, University of Washington, Seattle, WA
1991, Department of Anesthesiology and Critical Care, University of Chicago, Chicago, IL
1992, Neurobiology Research Laboratory, Veterans Affairs Medical Center, Duke University, Durham, NC
1993, Department of Biochemistry, Universidad Central del Caribe, Bayamon, PR
1993, Neurobiology Research Institute, San Juan, PR
1993, Roche Institute for Molecular Biology, Nutley, NJ
1994, Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD
1996, Department of Biology, University of Texas, Arlington, TX
1996, Department of Pharmacology, Medical College of Georgia, Augusta, GA
1998, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY

GRANTS AWARDED (AS P.I.)

Burrough Wellcome Fund, Wellcome Visiting Professorship in Physiology (Dr. Philip Schwartzkroin, Departments of Neurological Surgery and Physiology and Biophysics, University of Washington), Marshall University School of Medicine, 1996, $5000 total direct costs.

National Institutes of Health, Signaling Pathways in NMDA-Receptor Independent LTP, R01 NS34650, 1996-1999, $281,079 total direct costs.

PUBLICATIONS

Grover, L. and Farley, J. Temporal order sensitivity of associative neural and behavioral changes in Hermissenda. Behavioral Neuroscience 101, 658-675, 1987.

Grover, L., Farley, J. and Vold, L. Training and testing determinants of short-term associative suppression of phototaxic behavior in Hermissenda. Behavioral and Neural Biology 47, 275-306, 1987.

Auerbach, S., Grover, L. and Farley, J. Neurochemical and immunocytochemical analyses of serotonin in Hermissenda central nervous systems. Brain Research Bulletin 22, 353-361, 1989.

Grover, L. and Farley, J. Serotonin involvement during in vitro conditioning of Hermissenda. Brain Research Bulletin 22, 363-372, 1989.

Grover, L.M. & Teyler, T.J. Effects of extracellular potassium concentration and postsynaptic membrane potential on calcium-induced potentiation in area CA1 of rat hippocampus. Brain Research 506, 53-61, 1990.

Farley, J., Richards, W.G. & Grover, L.M. Associative learning changes intrinsic to Hermissenda Type A photoreceptors. Behavioral Neuroscience 104, 135-152, 1990.

Grover, L.M. & Teyler. Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation. Neuroscience Letters 113, 309-314, 1990.

Farley, J., Grover, L.M., Sun, L.M., Huang, S.S., Eisthen, H.L., Girolami, C. & Wu, R. Chemosensory conditioning of Hermissenda crassicornis. Behavioral Neuroscience 104, 583-596, 1990.

Grover, L.M. & Teyler, T.J. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347, 477-479, 1990.

Borroni, A., Chen, F.-M., LeCursi, N., Grover, L.M. & Teyler, T.J. An integrated multielectrode electrophysiology system. Journal of Neuroscience Methods 36, 177- 184, 1991.

Lambert, N.A., Borroni, A.M., Grover, L.M. & Teyler, T.J. Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus. Journal of Neurophysiology 66, 1538-1548, 1991.

Teyler, T., Aroniadou, V., Berry, R.L., Borroni, A., DiScenna, P., Grover, L. & Lambert, N. LTP in Neocortex. Seminars in the Neurosciences 2, 365-379, 1991.

Grover, L.M. & Teyler, T.J. N-methyl-D-aspartate receptor independent long-term potentiation in area CA1 of rat hippocampus: Input-specific induction and preclusion in a nontetanized pathway. Neuroscience 49, 7-11, 1992.

Patterson, S.L., Grover, L.M., Bothwell, M. & Schwartzkroin, P.A. Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9, 1082-1088, 1992.

Grover, L.M., Lambert, N.A., Schwartzkroin, P.A. & Teyler, T.L. Role of HCO3 ions in depolarizing GABAA receptor-mediated responses in pyramidal cells of rat hippocampus. Journal of Neurophysiology 69, 1541-1555, 1993.

Grover, L.M. & Teyler, T.J. Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus. Neuroscience Letters 154, 39-42, 1993.

Grover, L.M. & Teyler, T.J. Presynaptic mechanism for heterosynaptic, posttetanic depression in area CA1 of rat hippocampus. Synapse 15, 149-157, 1993.

Teyler, T.J. & Grover, L.M. Forms of long-term potentiation induced by NMDA and non-NMDA receptor activation. In Synaptic Plasticity: Molecular, Cellular and Functional Aspects. M. Baudry, R. Thompson & J.L. Davis (Eds.) MIT Press, 1993.

Grover, L.M. & Teyler, T.J. Activation of NMDA receptors in hippocampal area CA1 by low and high frequency orthodromic stimulation and their contribution to induction of long-term potentiation. Synapse16, 66-75, 1994.

Teyler, T., Cavus, I., Coussens, C., DiScenna, P., Grover, L., Lee, Y.P & Little, Z. Multideterminant role of calcium in hippocampal synaptic plasticity. Hippocampus 4, 623-634, 1994.

Grover, L.M. & Teyler, T.J. Different mechanisms may be required for maintenance of NMDA receptor dependent and independent forms of long-term potentiation. Synapse 19, 121-133, 1995.

Teyler, T., Cavus, I., Coussens, C., DiScenna, P., Grover, L., Lee, Y. & Little, Z. Advances in understanding the mechanisms underlying synaptic plasticity. In Brain Slices in Basic and Clinical Research. A. Schurr & B.M. Rigor (Eds.), CRC Press, 1995.

Lambert, N. & Grover, L. The mechanism of biphasic GABA responses. Science 269, 928-929, 1995.

Little, Z., Grover, L.M. & Teyler, T.J. Metabotropic glutamate receptor antagonist, (R,S)-a-methyl-4-carboxyphenylglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus, Neuroscience Letters 201, 73-76, 1995.

Grover. L.M. Evidence for postsynaptic induction and expression of NMDA receptor independent LTP, Journal of Neurophysiology 79, 1167-1182, 1998.

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