NAME: Lawrence M. Grover
ADDRESS:
Department of Physiology
Marshall University School of Medicine
1542 Spring Valley Drive
Huntington, WV 25755-9340
Telephone: 304-696-7328
Fax: 304-696-7381
Email: grover@marshall.edu
EDUCATION:
1982, B.S. Psychology, The University of the South, Sewanee, TN
1984, M.A. Psychology and Neuroscience, Princeton University,
Princeton, NJ
1986, Ph.D. Psychology and Neuroscience, Princeton University,
Princeton, NJ
HONORS AND AWARDS:
1978-82, National Merit Scholar, The University of the South,
Sewanee, TN
1985-86, Harold W. Dodds Fellow, Princeton University, Princeton,
NJ
PROFESSIONAL EXPERIENCE:
1982-1985, Assistant Instructor, Department of Psychology,
Princeton University, Princeton, NJ
1983-1985, Research Assistant, Department of Psychology,
Princeton University, Princeton, NJ
1986-1987, Research Associate, Department of Psychology,
Princeton University, Princeton, NJ
1988-1992, Research Associate, Neurobiology Department, N.E. Ohio
Universities College of Medicine, Rootstown, OH (Leave of
absence, 1990-1991)
1990-1991, Lecturer, Department of Psychology, University of
Washington, Seattle, WA
1992-1993, Research Assistant Professor, Neurobiology Department,
N.E. Ohio Universities College of Medicine, Rootstown, OH
1993-present, Assistant Professor, Department of Physiology,
Marshall University School of Medicine, Huntington, WV
PROFESSIONAL AFFILIATIONS:
1985-present, Society for Neuroscience
1996-present, American Physiological Society
TEACHING EXPERIENCE:
1. University of Washington (undergraduate):
Physiological Psychology
Advanced Physiological Psychology
Seminar in Learning and Memory
2. N.E. Ohio Universities College of Medicine (graduate):
Neurophysiology
3. Marshall University School of Medicine (undergraduate,
graduate and medical):
Cellular and Molecular Biology (BMS600)
Physiology of the Cell (PHS 666)
Neuroscience (BMS 630, IDM 777)
Mammalian Neurophysiology (PHS 628)
Neurophysiology Literature Review (PHS 637)
Recent Advance in Physiology (PHS 641)
Neurophysiology Research Techniques (PHS639)
Molecular Biology (BSC 450/550)
Molecular Signal Transduction (BIC 643)
INDSTITUTIONAL AND PROFESSIONAL SERVICE:
Faculty advisor, Program to Encourage Minority Scientists,
Marshall University School of Medicine, 1994-1997.
Recruitment trip for Marshall University School of Medicine to
West Liberty State, Bethany and Wheeling Jesuit Colleges, March
30-31, 1995. Seminar "How Does the Brain Store
Memories?", Bethany College, March 30, 1995.
Judge, Research Day, Marshall University School of Medicine,
1995, 1997.
Successful application for Spring 1996 Grass Foundation Traveling
Scientist in Neuroscience (Dr. Neil Harrison, Department of
Anesthesiology and Critical Care, University of Chicago),
Marshall University School of Medicine.
Outside evaluation for promotion review of Dr. Andrzej Wieraszko,
Biology Department, College of Staten Island, City University of
New York, 1996.
Department of Physiology Tenure and Promotion Committee, 1996.
Marshall University School of Medicine Personnel Committee,
1996-1998.
Marshall University School of Medicine Ad Hoc Committee on
Graduate Student Recruitment, 1997.
Marshall University School of Medicine External Institutional
Relationship Committee, 1997.
Reviewer for 1998 Conference of Southern Graduate Schools
Master's Thesis Award.
Reviewer for Brain Research, Brain Research Bulletin,
Experimental Neurology, Journal of Neurochemistry, Journal of
Neurophysiology, Journal of Neuroscience, Neuroscience.
RESEARCH INTERESTS:
Neural basis of learning and memory. Synaptic plasticity.
Excitatory and inhibitory amino acid neurotransmission.
Neurotransmitter and second messenger regulation of neuronal
excitability and synaptic transmission. Synaptic physiology of
the hippocampus.
DOCTORAL DISSERTATION:
Conditioning-produced short-term neural and behavioral changes in
Hermissenda: Ionic basis of, and neurotransmitter involvement in
cumulative depolarization of the Type B photoreceptor. Princeton
University, 1986.
INVITED SEMINARS:
1987, Neurobiology Department, N.E. Ohio Universities College of
Medicine, Rootstown, OH
1990, Department of Physiology and Biophysics, University of
Washington, Seattle, WA
1991, Department of Anesthesiology and Critical Care, University
of Chicago, Chicago, IL
1992, Neurobiology Research Laboratory, Veterans Affairs Medical
Center, Duke University, Durham, NC
1993, Department of Biochemistry, Universidad Central del Caribe,
Bayamon, PR
1993, Neurobiology Research Institute, San Juan, PR
1993, Roche Institute for Molecular Biology, Nutley, NJ
1994, Department of Pharmacology, Uniformed Services University
of the Health Sciences, Bethesda, MD
1996, Department of Biology, University of Texas, Arlington, TX
1996, Department of Pharmacology, Medical College of Georgia,
Augusta, GA
1998, Sanders-Brown Center on Aging, University of Kentucky,
Lexington, KY
GRANTS AWARDED (AS P.I.)
Burrough Wellcome Fund, Wellcome Visiting Professorship in
Physiology (Dr. Philip Schwartzkroin, Departments of Neurological
Surgery and Physiology and Biophysics, University of Washington),
Marshall University School of Medicine, 1996, $5000 total direct
costs.
National Institutes of Health, Signaling Pathways in
NMDA-Receptor Independent LTP, R01 NS34650, 1996-1999, $281,079
total direct costs.
PUBLICATIONS
Grover, L. and Farley, J. Temporal order sensitivity of
associative neural and behavioral changes in Hermissenda.
Behavioral Neuroscience 101, 658-675, 1987.
Grover, L., Farley, J. and Vold, L. Training and testing
determinants of short-term associative suppression of phototaxic
behavior in Hermissenda. Behavioral and Neural Biology 47,
275-306, 1987.
Auerbach, S., Grover, L. and Farley, J. Neurochemical and
immunocytochemical analyses of serotonin in Hermissenda central
nervous systems. Brain Research Bulletin 22, 353-361, 1989.
Grover, L. and Farley, J. Serotonin involvement during in vitro
conditioning of Hermissenda. Brain Research Bulletin 22, 363-372,
1989.
Grover, L.M. & Teyler, T.J. Effects of extracellular
potassium concentration and postsynaptic membrane potential on
calcium-induced potentiation in area CA1 of rat hippocampus.
Brain Research 506, 53-61, 1990.
Farley, J., Richards, W.G. & Grover, L.M. Associative
learning changes intrinsic to Hermissenda Type A photoreceptors.
Behavioral Neuroscience 104, 135-152, 1990.
Grover, L.M. & Teyler. Differential effects of NMDA receptor
antagonist APV on tetanic stimulation induced and calcium induced
potentiation. Neuroscience Letters 113, 309-314, 1990.
Farley, J., Grover, L.M., Sun, L.M., Huang, S.S., Eisthen, H.L.,
Girolami, C. & Wu, R. Chemosensory conditioning of
Hermissenda crassicornis. Behavioral Neuroscience 104, 583-596,
1990.
Grover, L.M. & Teyler, T.J. Two components of long-term
potentiation induced by different patterns of afferent
activation. Nature 347, 477-479, 1990.
Borroni, A., Chen, F.-M., LeCursi, N., Grover, L.M. & Teyler,
T.J. An integrated multielectrode electrophysiology system.
Journal of Neuroscience Methods 36, 177- 184, 1991.
Lambert, N.A., Borroni, A.M., Grover, L.M. & Teyler, T.J.
Hyperpolarizing and depolarizing GABAA receptor-mediated
dendritic inhibition in area CA1 of the rat hippocampus. Journal
of Neurophysiology 66, 1538-1548, 1991.
Teyler, T., Aroniadou, V., Berry, R.L., Borroni, A., DiScenna,
P., Grover, L. & Lambert, N. LTP in Neocortex. Seminars in
the Neurosciences 2, 365-379, 1991.
Grover, L.M. & Teyler, T.J. N-methyl-D-aspartate receptor
independent long-term potentiation in area CA1 of rat
hippocampus: Input-specific induction and preclusion in a
nontetanized pathway. Neuroscience 49, 7-11, 1992.
Patterson, S.L., Grover, L.M., Bothwell, M. & Schwartzkroin,
P.A. Neurotrophin expression in rat hippocampal slices: A
stimulus paradigm inducing LTP in CA1 evokes increases in BDNF
and NT-3 mRNAs. Neuron 9, 1082-1088, 1992.
Grover, L.M., Lambert, N.A., Schwartzkroin, P.A. & Teyler,
T.L. Role of HCO3 ions in depolarizing GABAA receptor-mediated
responses in pyramidal cells of rat hippocampus. Journal of
Neurophysiology 69, 1541-1555, 1993.
Grover, L.M. & Teyler, T.J. Role of adenosine in
heterosynaptic, posttetanic depression in area CA1 of
hippocampus. Neuroscience Letters 154, 39-42, 1993.
Grover, L.M. & Teyler, T.J. Presynaptic mechanism for
heterosynaptic, posttetanic depression in area CA1 of rat
hippocampus. Synapse 15, 149-157, 1993.
Teyler, T.J. & Grover, L.M. Forms of long-term potentiation
induced by NMDA and non-NMDA receptor activation. In Synaptic
Plasticity: Molecular, Cellular and Functional Aspects. M.
Baudry, R. Thompson & J.L. Davis (Eds.) MIT Press, 1993.
Grover, L.M. & Teyler, T.J. Activation of NMDA receptors in
hippocampal area CA1 by low and high frequency orthodromic
stimulation and their contribution to induction of long-term
potentiation. Synapse16, 66-75, 1994.
Teyler, T., Cavus, I., Coussens, C., DiScenna, P., Grover, L.,
Lee, Y.P & Little, Z. Multideterminant role of calcium in
hippocampal synaptic plasticity. Hippocampus 4, 623-634, 1994.
Grover, L.M. & Teyler, T.J. Different mechanisms may be
required for maintenance of NMDA receptor dependent and
independent forms of long-term potentiation. Synapse 19, 121-133,
1995.
Teyler, T., Cavus, I., Coussens, C., DiScenna, P., Grover, L.,
Lee, Y. & Little, Z. Advances in understanding the mechanisms
underlying synaptic plasticity. In Brain Slices in Basic and
Clinical Research. A. Schurr & B.M. Rigor (Eds.), CRC Press,
1995.
Lambert, N. & Grover, L. The mechanism of biphasic GABA
responses. Science 269, 928-929, 1995.
Little, Z., Grover, L.M. & Teyler, T.J. Metabotropic
glutamate receptor antagonist,
(R,S)-a-methyl-4-carboxyphenylglycine, blocks two distinct forms
of long-term potentiation in area CA1 of rat hippocampus,
Neuroscience Letters 201, 73-76, 1995.
Grover. L.M. Evidence for postsynaptic induction and expression
of NMDA receptor independent LTP, Journal of Neurophysiology 79,
1167-1182, 1998.