 |
|
|---|
| |
|
|---|
PROSPECTIVE
GRADUATE STUDENTS: There is an opening for at least one graduate
student in the lab. We have a small, congenial group and the BMS program offers
many unique opportunities in addition to your research training. Please contact
me by phone or e-mail for more information.
LAB
NEWS:
Undergraduates
Susie and Betsy Saunders completed their Capstone projects
in the lab and presented posters at Sigma Xi Research Day and at the Lexington
Symposium for Reproductive Science. The twins have graduated and plan to
continue their research as graduate students in Chemistry.
Grad
student T.J. Riddle was chosen to present a 10 minute talk at the School
of Medicine Research Day. He also presented a poster at the Lexington Symposium
and took second prize in the poster competition.
Major
Research Interests:
REGULATION
OF PITUITARY CELL FUNCTION. In my laboratory we use the regulated
expression of the prolactin gene by cultured rat pituitary tumor cells as a
model for the control of cellular differentiation. We have three major areas of
research. One is the regulation of prolactin gene expression by changes in
cell-cell adhesion. (Representative publication: P.R. Spangler and B.C. Delidow.
Co-regulation of pituitary tumor cell adhesion and prolactin gene expression by
glucocorticoid. J.Cell. Physiol., 174:115-124, 1998). These studies focus on the
alteration of ß-catenin expression by glucocorticoids.
We
have also found that retinoic acid profoundly alters the architecture of
235-1 cell cultures and that it rapidly induces expression of both prolactin and
the gap junction protein connexin 43. T.J. is continuing these studies for his
doctoral research. A
third focus is the control of tumor cell growth by glucocorticoids and the
expression of cell cycle regulatory proteins.
(Representative publication:
Delidow, et al., Glucocorticoid inhibition of 235-1 rat pituitary tumor cell
cycle progression, Endocrine 17: 119-127, 2002).
Achievement:
The
Marshall University Distinguished Artists and Scholars Award for Junior Faculty
(1999).
Lab alumni: "Where are they now?"
Two of my favorite bird-watching resources: